Yonezawa, Hidetoshi published the artcileDiscrepancy between the potency of various trypsin inhibitors to inhibit trypsin activity and the potency to release biologically active cholecystokinin-pancreozymin, Application of 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, the publication is Japanese Journal of Physiology (1984), 34(5), 849-56, database is CAplus and MEDLINE.
Injection of various trypsin??[9002-07-7] inhibitors into the lumen of the isolated perfused rat duodenum increased the amount of biol. active cholecystokinin-pancreozymin (CCK-BA) [9011-97-6] in the vascular perfusate. The potency to induce CCK-BA release of the various trypsin inhibitors diffeed. Injection of Et?p-(6-guanidinohexanoyloxy)benzoate?methanesulfonate (FOY-007) [56974-61-9] (100 ¦Ìmol); p-ethoxycarbamoylthio-6-guanidinocaproate phosphate (FOY-129) (110 ¦Ìmol); 4-(4-guanidinobenzoyloxy)phenylacetic?acid (FOY-251) [71079-09-9] (128 ¦Ìmol); N,N-dimethylcarbamoylmethyl-4-(4-guanidinobenoyloxy)phenylacetate?methanesulfonate (FOY-305) [59721-29-8] (80 ¦Ìmol); and p-aminobenzamidine-2HCl (p-ABA) [2498-50-2] (300 ¦Ìmol) caused release of CCK-BA amounting to 1042, 247, 252, 682, and 302 pM, resp. The potency to induce CCK-BA release was not correlated with the potency to inhibit trypsin activity. The present results do not support the hypothesis that a neg. feedback regulation of pancreatic enzyme secretion is exerted by intraluminal trypsin in the rat.
Japanese Journal of Physiology published new progress about 71079-09-9. 71079-09-9 belongs to catalysis-chemistry, auxiliary class Salt,Carboxylic acid,Carbamidine,Amine,Benzene,Ester,Protease,Ser/Thr Protease, name is 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt, and the molecular formula is C14H10O4S2, Application of 2-(4-((4-Guanidinobenzoyl)oxy)phenyl)acetic acid methanesulfonic acid salt.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia