Synthesis and biological evaluation of polyamine-porphyrin conjugates as potential agents in photodynamic therapy (PDT) was written by Lamarche, Francois;Sol, Vincent;Huang, Yi-Ming;Granet, Robert;Guilloton, Michel;Krausz, Pierre. And the article was included in Journal of Porphyrins and Phthalocyanines in 2002.Application In Synthesis of 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol The following contents are mentioned in the article:
A new class of porphyrins bearing natural polyamines, I [R = N(CH2CH2CH2NH2)(CH2CH2CH2CH2NH2); R = N(CH2CH2CH2NH2)(CH2CH2CH2CH2NHCH2CH2CH2NH2)], has been designed in order to target the photosensitizers towards malignant cells. The authors report the synthesis of spermidine and spermine porphyrins. Thus, spermidine was diprotected at the terminal amine functions and reacted with I (R = OH) followed by deprotection to give the desired product; spermine was reacted similarly. The photocytotoxicity of these compounds against K562 human chronic myelogenous leukemia cells has been evaluated and compared to Photofrin II. This study involved multiple reactions and reactants, such as 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5Application In Synthesis of 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol).
4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5) belongs to catalyst ligands. Ligand design occupies a central place in organic synthesis and catalysis. The ability of ligands to engender a variety of useful properties of organometallic complexes is the major enabling force for the discovery of new catalytic reactions, activation of small molecules, dramatically enhanced reactivity.Application In Synthesis of 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI