Polyamine conjugates of meso-tritolylporphyrin and protoporphyrin IX: Potential agents for photodynamic therapy of cancers was written by Sol, Vincent;Lamarche, Francois;Enache, Michaela;Garcia, Guillaume;Granet, Robert;Guilloton, Michel;Blais, J. C.;Krausz, Pierre. And the article was included in Bioorganic & Medicinal Chemistry in 2006.Computed Properties of C47H36N4O The following contents are mentioned in the article:
An efficient five-step synthesis method was developed to obtain tritolylporphyrin and protoporphyrin IX polyamine conjugates. These compounds were composed of either one polyamine unit (spermidine or spermine) covalently tethered to monocarboxyphenyl tritolylporphyrin or two mols. of polyamines borne by protoporphyrin IX. In each compound, an aliphatic spacer arm is linked to the N 4 polyamine position. Photocytotoxicity of these new compounds was evaluated against K562 human chronic myelogenous leukemia cells and compared to Photofrin II; protoporphyrin IX polyamine conjugates exhibited much stronger photocytocicity than Photofrin II and were shown to readily induce necrosis in treated cells. This study involved multiple reactions and reactants, such as 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5Computed Properties of C47H36N4O).
4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5) belongs to catalyst ligands. Ligand, in chemistry, any atom or molecule attached to a central atom, usually a metallic element, in a coordination or complex compound. Replacing precious metals with cheaper and more environmentally friendly metals is regarded as a highly desirable goal in the field of catalysis.Computed Properties of C47H36N4O
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI