Porphyrins: synthesis and antitumor activity of porphyrin-fluorouracil compounds was written by Huang, S. Q.;Jiang, Z. C.;Li, L. Z.;Xu, J. Y.;Yang, J.. And the article was included in Yaoxue Xuebao in 1991.Electric Literature of C47H36N4O The following contents are mentioned in the article:
Three covalently linked porphyrin-fluorouracil compounds I (R1 = H, R2 = o-NHCOCH2Q (II), R1 = MeO, R2 = p-O(CH2)4Q; R1 = Me, R1 = p-O(CH2)4Q] were synthesized. Measurement using these compounds for inhibition of mice transplanted tumor growth, cytotoxicity to mice cancer cells and the mice ear index under exposure to a light was performed. The results indicated that all these compounds were phototoxic to the cancer cells, and compound II was the most effective among them. This study involved multiple reactions and reactants, such as 4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5Electric Literature of C47H36N4O).
4-(10,15,20-Tri-p-tolylporphyrin-5-yl)phenol (cas: 57412-08-5) belongs to catalyst ligands. Ligands are classified based on the number of lone pair electrons available for the central metal atom, size and charge like anionic, cationic, neutral, monodentate, bidentate, polydentate ligands. The ability of ligands to engender a variety of useful properties of organometallic complexes is the major enabling force for the discovery of new catalytic reactions, activation of small molecules, dramatically enhanced reactivity.Electric Literature of C47H36N4O
Referemce:
Metal catalyst and ligand design,
Ligand Template Strategies for Catalyst Encapsulation – NCBI