Arafa, Reem K. published the artcileSynthesis, DNA Affinity, and Antiprotozoal Activity of Fused Ring Dicationic Compounds and Their Prodrugs, Related Products of catalysis-chemistry, the publication is Journal of Medicinal Chemistry (2005), 48(17), 5480-5488, database is CAplus and MEDLINE.
Dicationic guanidine, N-alkylguanidine, and reversed amidine derivatives of fused ring systems (e.g. I, II) have been synthesized from their corresponding bis-amines. DNA binding studies suggest that the diguanidines and the N-alkyl diguanidine fluorenes bind in the minor groove in a manner similar to that of the previously reported dicationic carbazole derivatives The diguanidines and the N-alkyl diguanidines showed promising in vitro activity against both Trypanosoma brucei rhodesiense and Plasmodium falciparum. Promising in vivo biol. results were obtained for the dicationic N-isopropylguanidino-9H-fluorene (I), giving 4/4 cures of the treated animals in the STIB900 animal model for African trypanosomiasis. The N-Me analog showed high activity as well. In addition, with the goal of enhancing the oral bioavailability, two novel classes of potential guanidine prodrugs were prepared The N-alkoxyguanidine derivatives and were not effective as prodrugs. In contrast, a number of the carbamates showed promising activity. The value of the carbamate prodrugs was clearly demonstrated by the results for II, which gave 4/4 cures on oral administration in the STIB900 mouse model.
Journal of Medicinal Chemistry published new progress about 6084-58-8. 6084-58-8 belongs to catalysis-chemistry, auxiliary class Salt,Amine,Aliphatic hydrocarbon chain, name is O-Isobutylhydroxylamine hydrochloride, and the molecular formula is C4H12ClNO, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia