Carreiro, Elisabete Palma published the artcileArylid-OX and Arylid-BOX derived catalysts: applications in catalytic asymmetric cyclopropanation, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, the publication is Tetrahedron: Asymmetry (2009), 20(11), 1272-1278, database is CAplus.
A novel family of chiral non-racemic monodentate oxazoline ligands known as Arylid-OXs I (R = Ph, t-Bu) was prepared in good overall yields. These ligands were screened in bench-mark Cu(I)-catalyzed cyclopropanations and gave ees as high as 58%. Both 1H NMR and computational studies using I (R= Ph) indicated that the active catalyst was most likely to be the di-coordinated complex, Cu(I)-I (R= Ph)2 (MeCN)2. Two novel ortho-substituted Arylid-BOX ligands II (X = Cl, OMe) were also synthesized in very good yields. These ligands were tested in the same reaction as for I (R = Ph, t-Bu) and, although excellent yields could be obtained with II (R = OMe), which is assumed to be due to an electron-donating effect from the ortho-methoxy group, a best ee of only 56% was obtained with II (R = Cl). In fact, both the enantioselectivities and diastereoselectivities obtained with these ortho-substituted ligands were in line with those previously obtained with the para-substituted series.
Tetrahedron: Asymmetry published new progress about 16909-09-4. 16909-09-4 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Benzene,Ether, name is (E)-3-(2,4-Dimethoxyphenyl)acrylic acid, and the molecular formula is C11H12O4, Recommanded Product: (E)-3-(2,4-Dimethoxyphenyl)acrylic acid.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia