Zhang, Hanwen published the artcileAn improved strategy for the synthesis of [18F]-labeled arabinofuranosyl nucleosides, Category: catalysis-chemistry, the publication is Nuclear Medicine and Biology (2012), 39(8), 1182-1188, database is CAplus and MEDLINE.
The expression of the herpes simplex virus type-1 thymidine kinase (HSV1-tk) gene can be imaged efficaciously using a variety of 2′-[18F]fluoro-2′-deoxy-1-¦Â-D-arabinofuranosyl-uracil derivatives [18F]-F(X)AU (X = I, Et, Me), e.g. I. However, the application of these derivatives in clin. and translational studies has been impeded by their complicated and long syntheses (3-5 h). To remedy these issues, in the study at hand we have investigated whether microwave or combined catalysts could facilitate the coupling reaction between sugar and nucleobase and, further, have probed the feasibility of establishing a novel approach for [18F]-F(X)AU synthesis. We have demonstrated that the rate of the trimethylsilyl trifluoromethanesulfonate (TMSOTf)-catalyzed coupling reaction between the 2-deoxy-sugar and uracil derivatives at 90 ¡ãC can be significantly accelerated by microwave-driven heating or by the addition of Lewis acid catalyst (SnCl4). Further, we have observed that the stability of the ¦Á- and ¦Â-anomers of [18F]-F(X)AU derivatives differs during the hydrolysis step. Using the microwave-driven heating approach, overall decay-corrected radiochem. yields of 19%-27% were achieved for [18F]-FXAU in 120 min at a specific activity of > 22 MBq/nmol (595 Ci/mmol). Ultimately, we believe that these high yielding syntheses of [18F]-F(I)AU, [18F]-F(Me)AU and [18F]-F(Et)AU will facilitate routine production for clin. applications.
Nuclear Medicine and Biology published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C8H7ClO3, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia