Sefi, Mediha published the artcileAntioxidant role of selenium against maneb-induced cardiotoxicity in mice, Quality Control of 6217-54-5, the publication is Environmental Science and Pollution Research (2022), 29(36), 54827-54841, database is CAplus and MEDLINE.
The current study was conducted to assess the beneficial effect of selenium (Se) on maneb-induced cardiotoxicity and fatty acid alterations in adult mice. Swiss albino male mice were assigned into four exptl. groups. The first group consisted of neg. controls. The second group represented the pos. controls where mice received daily, via the diet, sodium selenite at a dose of 0.2 mg/kg. For the third group, mice were subjected to i.p. injections of maneb (30 mg/kg BW). The fourth group (MB+Se) received daily the same dose of maneb as group 3 along with sodium selenite at the same dose as group 2. Mice exposure to maneb caused cardiotoxicity as indicated by an increase in malondialdehyde, hydrogen peroxide, and protein carbonyl levels, and an alteration of the antioxidant defense system (catalase, glutathione peroxidase, superoxide dismutase, glutathione, and vitamin C). Plasma lactate dehydrogenase activity and total cholesterol, triglyceride, and low-d. lipoprotein cholesterol levels increased, while high-d. lipoprotein cholesterol level decreased. Results showed also a decrease in the amount of n-3 PUFA, docosahexaenoic, docosapentaenoic, and eicosapentaenoic acids. However, an increase in the levels of MUFA, cis-vaccenic, and palmitoleic acids was observed Co-administration of Se restored the parameters indicated above to near control values. The histopathol. findings confirmed the biochem. results. Selenium could be a useful and efficient agent against maneb-induced cardiotoxicity.
Environmental Science and Pollution Research published new progress about 6217-54-5. 6217-54-5 belongs to catalysis-chemistry, auxiliary class Alkenyl,Carboxylic acid,Aliphatic hydrocarbon chain,Metabolic Enzyme,RAR/RXR,Natural product, name is Docosahexaenoic Acid, and the molecular formula is C9H8BNO2, Quality Control of 6217-54-5.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia