Tay, Nicholas E. S. published the artcile19F- and 18F-arene deoxyfluorination via organic photoredox-catalysed polarity-reversed nucleophilic aromatic substitution, SDS of cas: 17351-62-1, the publication is Nature Catalysis (2020), 3(9), 734-742, database is CAplus and MEDLINE.
Nucleophilic aromatic substitution (SNAr) is routinely used to install 19F- and 18F- in aromatic mols., but it is typically limited to electron-deficient arenes due to kinetic barriers associated with C-F bond formation. A polarity-reversed photoredox-catalyzed arene deoxyfluorination that operates via cation-radical-accelerated SNAr enables the fluorination of electron-rich arenes 4-ClC6H4OR (R = 4-phenylphenyl, 3-methoxypyridin-2-yl, 2,4-bis(tert-butoxy)pyrimidin-5-yl, 4-[(2S)-2-([(tert-butoxy)carbonyl]amino)-3-methoxy-3-oxopropyl]benzen-1-yl, etc.) with 19F- and 18F- under mild conditions, and thus complements the traditional arene polarity requirements necessary for SNAr-based fluorination. The utility of radiofluorination strategy is highlighted by short reaction times, compatibility with multiple nucleofuges and high radiofluorination yields 18FR, especially that of an important cancer positron emission tomog. agent [18F]5-fluorouracil. Taken together, fluorination approach enables the development of fluorinated 19FR and radiofluorinated compounds 18FR that can be difficult to access by classical SNAr strategies, with the potential for use in the synthesis and discovery of positron emission tomog. radiopharmaceuticals.
Nature Catalysis published new progress about 17351-62-1. 17351-62-1 belongs to catalysis-chemistry, auxiliary class Salt,Amine, name is Tetrabutylammonium hydrogencarbonate, and the molecular formula is C10H11NO4, SDS of cas: 17351-62-1.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia