Fang, Hongbin published the artcileSynthesis and biological activity of amide derivatives derived from natural product Waltherione F, Related Products of catalysis-chemistry, the publication is Medicinal Chemistry Research (2022), 31(3), 485-496, database is CAplus.
Structural optimization based on natural products has become an effective way to develop new fungicides, which provides important guiding significance for practicing the new development concept and promoting the green development of pesticides. In this project, the target compounds containing 4-quinolone and piperazine substructures based on waltherione F were synthesized through the combination of the fungicidal amide lead compound X-I-4 discovered in our previous work and various of fungicidal piperazine derivatives Screening of their biol. activities suggested that products I-3, I-5, II-3, II-7, II-10, II-11 and II-13 displayed higher inhibition rates against Rhizoctonia solani than other tested compounds The in vitro cellular cytotoxicity assay revealed that compounds II-6 and II-11 exhibited higher cytotoxicity against HepG2 than other tested compounds The fluorescence characteristics investigation showed that the absolute fluorescence QY value of the methanol solution of the compound I-6 was higher than those of I-2, I-3, I-7 and I-8, which was further elucidated by TD-DFT.
Medicinal Chemistry Research published new progress about 118-90-1. 118-90-1 belongs to catalysis-chemistry, auxiliary class Carboxylic acid,Benzene,Natural product, name is 2-Methylbenzoic acid, and the molecular formula is C8H8O2, Related Products of catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia