Levitskaia, Tatiana G. published the artcileEvaluation of cuprimine and syprine for decorporation of radioisotopes of cesium, cobalt, iridium and strontium, Quality Control of 38260-01-4, the publication is Health Physics (2011), 101(2), 118-127, database is CAplus and MEDLINE.
Cuprimine and Syprine are therapeutics approved by the USFDA to treat copper overload in Wilson Disease (a genetic defect in copper transport) by chelation and accelerated excretion of internally-deposited copper. These oral therapeutics are based on the resp. active ingredients D-penicillamine (DPA) and N,N’-bis (2-aminoethyl) -1,2-ethanediamine dihydrochloride (Trien). Cuprimine is considered the primary treatment, although physicians are increasingly turning to Syprine as a first-line therapy. Both drugs exhibit oral systemic activity and low toxicity; their biol. effects and safety are established. Previous in vivo studies using a rodent animal model established the decorporation potential of Cuprimine and Syprine for Co and Po. Currently these studies are being expanded to evaluate the in vivo decorporation efficacy of these drugs for several addnl. radionuclides. In this report, results of this investigation are discussed using the radionuclides Cs, Co, Ir and Sr. Short-term 48-h pilot studies were undertaken to evaluate DPA and Trien for their in vivo decorporation potential using male Wistar-Han rats. In these studies, a radionuclide solution was administered to the animals by i.v. (IV) injection, followed by a single IV dose of either DPA or Trien. Control animals received the radionuclide alone. Results show effective decorporation of Co by DPA within the time frame evaluated. DPA and Trien were also modestly effective in decorporation of Cs and Sr, resp. The study did not find DPA or Trien effective for decorporation of Ir. Based on these encouraging findings, further studies to evaluate the dose-response profiles and timing of the chelator administration post exposure to radionuclides are warranted.
Health Physics published new progress about 38260-01-4. 38260-01-4 belongs to catalysis-chemistry, auxiliary class Chelating Agents, name is N1,N1′-(Ethane-1,2-diyl)bis(ethane-1,2-diamine) dihydrochloride, and the molecular formula is C6H20Cl2N4, Quality Control of 38260-01-4.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia