Eremina, Olga E. published the artcileExpanding the multiplexing capabilities of Raman imaging to reveal highly specific molecular expression and enable spatial profiling, SDS of cas: 13822-56-5, the publication is ACS Nano (2022), 16(7), 10341-10353, database is CAplus and MEDLINE.
Profiling the heterogeneous landscape of cell types and biomols. is rapidly being adopted to address current imperative research questions. Precision medicine seeks advancements in mol. spatial profiling techniques with highly multiplexed imaging capabilities and subcellular resolution, which remains an extremely complex task. Surface-enhanced Raman spectroscopy (SERS) imaging offers promise through the utilization of nanoparticle-based contrast agents that exhibit narrow spectral features and mol. specificity. The current renaissance of gold nanoparticle technol. makes Raman scattering intensities competitive with traditional fluorescence methods while offering the added benefit of unsurpassed multiplexing capabilities. Here, we present an expanded library of individually distinct SERS nanoparticles to arm researchers and clinicians. Our nanoparticles consist of a 6?0 nm gold core, a Raman reporter mol., and a final inert silica coating. Using d. functional theory, we have selected Raman reporters that meet the key criterion of high spectral uniqueness to facilitate unmixing of up to 26 components in a single imaging pixel in vitro and in vivo. We also demonstrated the utility of our SERS nanoparticles for targeting cultured cells and profiling cancerous human tissue sections for highly multiplexed optical imaging. This study showcases the far-reaching capabilities of SERS-based Raman imaging in mol. profiling to improve personalized medicine and overcome the major challenges of functional and structural diversity in proteomic imaging.
ACS Nano published new progress about 13822-56-5. 13822-56-5 belongs to catalysis-chemistry, auxiliary class Organic Silicones, name is 3-(Trimethoxysilyl)propan-1-amine, and the molecular formula is C6H17NO3Si, SDS of cas: 13822-56-5.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia