Ozalp, Lalehan published the artcileInvestigation of HMG-CoA reductase inhibitory and antioxidant effects of various hydroxycoumarin derivatives, HPLC of Formula: 104-03-0, the publication is Archiv der Pharmazie (Weinheim, Germany) (2020), 353(10), 1900378, database is CAplus and MEDLINE.
Cardiovascular diseases are one of the primary causes of deaths worldwide, and the development of atherosclerosis is closely related to hypercholesterolemia. As the reduction of the low-d. lipoprotein cholesterol level is critical for treating these diseases, the inhibition of 3-hydroxy-3-methyl-glutaryl CoA (HMG-CoA) reductase, which is essentially responsible for cholesterol biosynthesis, stands out as a key solution to lower plasma cholesterol levels. In this study, we synthesized several dihydroxycoumarins and investigated their antioxidant and in vitro HMG-CoA reductase inhibitory effects. Furthermore, we carried out in silico studies and examined the quantum-chem. properties of the coumarin derivatives We also performed mol. docking experiments and analyzed the binding strength of each coumarin derivative Our results revealed that compound IV(I) displayed the highest HMG-CoA reductase inhibitory activity (IC50 = 42.0 ¦ÌM) in vitro. Cupric-reducing antioxidant capacity and ferric-reducing antioxidant power assays demonstrated that coumarin derivatives exhibit potent antioxidant activities. Addnl., a close relationship was found between the LUMO energy levels and the antioxidant activities.
Archiv der Pharmazie (Weinheim, Germany) published new progress about 104-03-0. 104-03-0 belongs to catalysis-chemistry, auxiliary class Nitro Compound,Carboxylic acid,Benzene, name is 4-Nitrophenylacetic acid, and the molecular formula is C8H7NO4, HPLC of Formula: 104-03-0.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia