Makai, Szabolcs published the artcileDirect Synthesis of Unprotected 2-Azidoamines from Alkenes via an Iron-Catalyzed Difunctionalization Reaction, Category: catalysis-chemistry, the publication is Journal of the American Chemical Society (2020), 142(51), 21548-21555, database is CAplus and MEDLINE.
Unprotected, primary 2-azidoamines are versatile precursors to vicinal diamines, which are among the most common motifs in biol. active compounds Herein, we report their operationally simple synthesis through an iron-catalyzed difunctionalization of alkenes. A wide array of alkene substrates are tolerated, including complex drug-like mols. and a tripeptide. Facile derivatizations of the azidoamine group demonstrate the versatility of this masked diamine motif in chemoselective, orthogonal transformations. Applications of the methodol. in the concise synthesis of RO 20-1724 as well as in the formal total syntheses of both (¡À)-hamacanthin B and (¡À)-quinagolide further demonstrate the broad synthetic potential of this highly functional-group-tolerant reaction.
Journal of the American Chemical Society published new progress about 1293990-73-4. 1293990-73-4 belongs to catalysis-chemistry, auxiliary class Aliphatic Chain, name is O-Pivaloylhydroxylamine trifluoromethanesulfonate, and the molecular formula is C6H12F3NO5S, Category: catalysis-chemistry.
Referemce:
https://courses.lumenlearning.com/boundless-chemistry/chapter/catalysis/,
Catalysis – Wikipedia